HIV specific antibody - dependent phagocytosis ( ADP ) matures during HIV infection

نویسندگان

  • Haiyin Liu
  • Rob J. Center
  • Supachai Rerks-Ngarm
  • Punnee Pitisuttithum
  • Sorachai Nitayaphan
  • Jaranit Kaewkungwal
  • Jerome H. Kim
  • Nelson L. Michael
  • Anthony D Kelleher
  • Ivan Stratov
  • Stephen J. Kent
  • Marit Kramski
چکیده

1 Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, Australia 2 Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia 3 Burnet Institute, 85 Commercial Road, Melbourne, Australia 4 Department of Disease Control, Ministry of Public Health, Bangkok, Thailand 5 Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 6 Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand 7 Data Management Unit, Mahidol University, Bangkok, Thailand 8 U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, USA

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

HIV-specific antibody-dependent phagocytosis matures during HIV infection.

Antibody-dependent phagocytosis (ADP) is a potentially important immune mechanism to clear HIV. How HIV-specific ADP responses mature during HIV infection or in response to vaccinations administered, including the partially successful RV144 HIV vaccine, is not known. We established a modified ADP assay to measure internalisation of HIV antibody (Ab)-opsonised targets using a specific hybridisat...

متن کامل

Antibody-dependent effector functions against HIV decline in subjects receiving antiretroviral therapy.

BACKGROUND Combination antiretroviral therapy (cART) effectively controls human immunodeficiency virus (HIV) infection but does not eliminate HIV, and lifelong treatment is therefore required. HIV-specific cytotoxic T lymphocyte (CTL) responses decline following cART initiation. Alterations in other HIV-specific immune responses that may assist in eliminating latent HIV infection, specifically ...

متن کامل

Human immunodeficiency virus type-1 (HIV-1) evades antibody-dependent phagocytosis

Fc gamma receptor (FcyR)-mediated antibody functions play a crucial role in preventing HIV infection. One such function, antibody-dependent phagocytosis (ADP), is thought to be involved in controlling other viral infections, but its role in HIV infection is unknown. We measured the ability of HIV-specific polyclonal and monoclonal antibodies (mAbs) to mediate the internalization of HIV-1 virion...

متن کامل

راه‌اندازی و به‌کارگیری روش الیزا به‌منظور تشخیص حضور آنتی‌ژن p24 در خون افراد آلوده به HIV

Introduction: Human immunodeficiency virus is the etiologic agent of immune system deficiency and the infected patients are susceptible to opportunistic infections and AIDS. Transmission of infection during blood transfusion and diagnosis of infection in hospitals and public health settings have steadily been a worldwide concern. Different techniques are now available for the diagnosis of HIV i...

متن کامل

Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control

Elite controllers (ECs) represent a unique model of a functional cure for HIV-1 infection as these individuals develop HIV-specific immunity able to persistently suppress viremia. Because accumulating evidence suggests that HIV controllers generate antibodies with enhanced capacity to drive antibody-dependent cellular cytotoxicity (ADCC) that may contribute to viral containment, we profiled an ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016